Prazosin: severe side effects are dose-dependent.
نویسندگان
چکیده
منابع مشابه
Acute haemodynamic effects of oral prazosin in severe mitral regurgitation.
Acute haemodynamic effects of single dose oral prazosin were studied in eight patients with mitral regurgitation. Heart rate, mean systemic arterial pressure, pulmonary arterial pressure, left ventricular filling pressure, and forward cardiac output were measured in all patients. At peak effect, prazosin reduced mean systemic arterial pressure (95 +/- 4 to 86 +/- 4 mmHg), pulmonary arterial pre...
متن کاملEffects of Prazosin
The left ventricular (LV) and coronary vascular effects of prazosin, a drug that reduces peripheral vascular resistance by blocking postsynaptic a receptors, were examined in conscious dogs. Prazosin, 0.07 mg/kg/mmn i.v. for 7 minutes, induced sustained hypotensive effects for more than 12 hours. The peak effects occurred 3045 minutes after administration. Prazosin increased heart rate by 28 ± ...
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CASE REPORTS We describe 2 patients who developed ocular side effects during treatment with topiramate. One was a 16-year-old woman with generalized seizures who developed a homonymous hemianopia after using topiramate 125 mg per day for 12 weeks, and the other was a 24-year-old epileptic female who developed a bilateral maculopathy after using topiramate 150 mg per day for 8 weeks. DISCUSSIO...
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Opiates have complex effects on seizure thresholds as these substances have both anti and proconvulsive actions in the mammalian brain. A reduction of inhibitory synaptic activity or enhancement of excitatory synaptic activity would be expected to trigger a seizure. This study is designed to determine how morphine and naloxone affect seizures induced by a low Mg2+ perfusate in the whole, intact...
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ژورنال
عنوان ژورنال: BMJ
سال: 1976
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6034.508